C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0789 (2010.01) C12N 5/071 (2010.01)
Patent
CA 2565115
The present invention provides methods, culture media, and apparatus to produce useful amounts of specific cell populations ex vivo by the modulation of Opn and/or an active Opn fragment. The present invention provides ex vivoexpanded populations of HSC for use in transplantation therapy and in clinical and research activities, such as drug screening, toxicity testing, and other research activities. Also provided are methods, devices and culture media are provided to inhibit Opn binding to HISC to promote the increased production of more differentiated cell populations.
L'invention concerne des méthodes, un milieu de culture et un appareil permettant de produire ex vivo des quantités utilisables de populations de cellules spécifiques par modulation d'Opn et/ou d'un fragment actif d'Opn. L'invention permet également de produire ex vivo des populations étendues de HSC utilisées dans une thérapie de transplantation et dans des activités cliniques et de recherche, telles que des analyses de médicaments, des essais de toxicité et d'autres activités de recherche. L'invention concerne également des méthodes, des dispositifs et des milieux de culture permettant d'inhiber la liaison d'Opn à HISC afin de promouvoir une production accrue de populations de cellules différenciées.
Haylock David Norman
Nilsson Susan K.
Simmons Paul John
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Peter Maccallum Cancer Institute
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