Methods for sterilizing preparations containing albumin

Details Methods for sterilizing preparations containing albumin Methods for sterilizing preparations containing albumin

A - Human Necessities

61

L

A61L 2/08 (2006.01) A01N 1/02 (2006.01) A61K 38/38 (2006.01) A61L 2/00 (2006.01)

Patent

CA 2459413

Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations containing albumin, such as plasma protein fractions, with irradiation.

L'invention concerne des procédés de stérilisation de préparations contenant de l'albumine. Ces procédés permettent de réduire le niveau d'un ou de plusieurs contaminants biologiques actifs ou pathogènes, tels que des virus, des bactéries (y compris les bactéries intercellulaires et les bactéries intracellulaires, telles que les mycoplasmes, les uréaplasmes, les nanobactéries, les chlamydia ou les rickettsies), des levures, des moisissures, des champignons, des prions ou des agents similaires responsables, utilisés séparément ou de façon combinée, des TSE et/ou parasites unicellulaires ou multicellulaires. Ces procédés concernent des préparations de stérilisation contenant de l'albumine, telles que des fractions de protéine plasmatique, au moyen d'une radioexposition.

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