A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01)
Patent
CA 2172808
The present invention relates to methods of using oncostatin M (OM). In particular, it relates to the use of OM to stimulate interleukin 6 (IL-6) synthesis in target cells, especially human endothelial cells. The resultant IL-6, in turn, may perform a variety of functions such as cell growth regulation, leukocyte differentiation, and tumor inhibition. Furthermore, the present invention also relates to the use of OM to treat cytopenias, including anemia and thrombocytopoiesis, and to increase toleranoe to irradiation and cytotoxic drugs. Therefore, the methods of the invention may have a wide range of applications, including, but not limited to, the inhibition of tumor growth, the treatment of cytopenias, and to increase the tolerance to radio- and chemotherapy. OM may be used in combination with various cytokines, including erythropoietin, colony-stimulating factors, inerleukin-3 or thrombopoietin.
La présente invention a pour objet des procédés d'utilisation de l'oncostatine-M (OM). Elle concerne en particulier l'utilisation d'OM pour stimuler la synthèse d'interleukine-6 (IL-6) dans des cellules cibles, en particulier des cellules endothéliales humaines. L'IL-6 ainsi produite peut exécuter diverses fonctions telles que la régulation de la croissance cellulaire, la différenciation des leucocytes et l'inhibition des tumeurs. La présente invention se rapporte en outre à l'utilisation de l'OM pour traiter les cytopénies, y compris l'anémie et la thrombocytopoïèse, et pour augmenter la tolérance aux rayonnements et aux médicaments cytotoxiques. Les procédés selon l'invention permettent donc des utilisations variées, notamment, mais non exclusivement, l'inhibition de la croissance tumorale, le traitement des cytopénies, et l'augmentation de la tolérance à la radiothérapie et à la chimiothérapie. L'OM peut être utilisée en association avec diverses cytokines, notamment l'érythropoïétine, les facteurs de stimulation de colonies, l'interleukine-3 ou la thrombopoïétine.
Brown Thomas J.
Wallace Philip M.
Bristol-Myers Squibb Company
Ridout & Maybee Llp
LandOfFree
Methods for stimulating interleukin-6 synthesis and inducing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for stimulating interleukin-6 synthesis and inducing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for stimulating interleukin-6 synthesis and inducing... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1629973