G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/573 (2006.01) C12Q 1/26 (2006.01) G01N 30/72 (2006.01) G01N 33/557 (2006.01)
Patent
CA 2500932
The present invention relates to a method of screening compounds for modulation and binding to proteins, in particular proteins that have been immobilized in a monolithic chromatographic stationary phase. The method involves observing the conversion of a substrate to product by the protein and determining a product to substrate ratio. Changes in this ratio in the presence of another compound indicates that the other compound is a modulator of the enzyme. Various applications of this method to compound screening, including high throughput screening formats, are described.
Besanger Travis
Brennan John D.
Brook Michael A.
Hodgson Richard
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Mcmaster University
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