C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) C12N 5/078 (2010.01) A01K 67/027 (2006.01) A01N 1/02 (2006.01) A61K 35/12 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2592716
Provided are methods for culturing and producing human cell containing compositions, such as organs and blood, in non-human mammal hosts and for the preparation of animal~hosted human cell containing compositions for transplantation to human subjects. In one aspect, non-human hosts genetically modified or treated to reduce the expression of xenoantigens, such as alpha- galactosyl epitopes, are used to reduce the transfer of xenoantigens to the hosted human cells. In another aspect, non-human hosts genetically modified to express or over-express molecules that promote immunological tolerance to a graft, such as hDAF, are used so that the molecules are transferred to the hosted human cells. These aspects facilitate the immunological acceptance of the human cell containing compositions upon transplantation to a human subject. Still another aspect provides conditioning treatments that facilitate the immunological acceptance of human cell containing compositions that have been supported in non-human hosts upon their transplantation to a human subject.
L'invention porte sur des méthodes de mise en culture et de production de compositions contenant des cellules humaines, telles que des organes et du sang, dans des hôtes mammaliens, et sur des méthodes de préparation de ces compositions contenant des cellules humaines hébergées dans un animal en vue de leur transplantation à l'homme. Selon une variante, on utilise des hôtes non humains modifiés ou traités génétiquement afin de réduire l'expression de xénoantigènes, tels que des épitopes alpha-galactosyle, pour limiter le transfert des xénoantigènes dans les cellules humaines hébergées. Selon une autre variante, on utilise des hôtes non humains génétiquement modifiés pour exprimer ou surexprimer des molécules qui favorisent la tolérance immunologique sur une greffe, telles que hDAF, de sorte que les molécules soient transférées dans les cellules humaines hébergées. Ces variantes facilitent l'acceptation immunologique des compositions contenant les cellules humaines lors de leur transplantation chez l'homme. Selon une autre variante, des traitements de conditionnement facilitent l'acceptation immunologique, lors de leur transplantation chez l'homme, des compositions contenant les cellules humaines qui ont été hébergées dans des hôtes non humains.
Diamond Paul
Moffat & Co.
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