Methods for suppressing tumor proliferation

Details Methods for suppressing tumor proliferation Methods for suppressing tumor proliferation

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61K 31/7105 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2560046

It is intended to provide a method of inhibiting tumor proliferation which comprises the step of inhibiting the expression of PDGF-A or the binding of PDGF-A homodimer to PDGFR.alpha.. Activation of the PDGFR .alpha.-p70S6K signal transfer pathway by PDGF-AA, which is an important factor in tumor angiogenesis, relates to the prognosis of a patient suffering from tumor. By inhibiting the expression of PDGF-A in a tumor or a tissue around it or by inhibiting the binding of PDGF-A homodimer to PDGFR.alpha., angiogenesis in the tumor and retention of the blood vessels can be inhibited and thus the tumor proliferation can be inhibited.

L'intention est de fournir un procédé d'inhibition de la prolifération d'une tumeur lequel comprend l'étape consistant à inhiber l'expression du PDGF-A ou la formation d'une liaison entre l'homodimère du PDGF-A et le PDGFR.alpha.. L'activation de la voie de transmission de signal PDGFR.alpha.-p70S6K par le PDGF-AA, laquelle est un facteur important dans l'angiogenèse de tumeurs, est liée au pronostic d'un patient souffrant d'une tumeur. En inhibant l'expression du PDGF-A dans une tumeur ou un tissu autour d'elle ou bien en inhibant la formation de liaison entre l'homodimère du PDGF-A et le PDGFR.alpha., on peut éviter l'angiogenèse dans la tumeur et la rétention des vaisseaux sanguins et ainsi on peut inhiber la prolifération de la tumeur.

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