Methods for synthesis of 3-amino-1-arylpropyl indoles

Details Methods for synthesis of 3-amino-1-arylpropyl indoles Methods for synthesis of 3-amino-1-arylpropyl indoles

C - Chemistry, Metallurgy

07

D

C07D 209/14 (2006.01) C07D 209/18 (2006.01)

Patent

CA 2631048

A method comprising: hydrogenating an indole propionamide compound of formula h with vitride, to form an aminopropyl indole compound of formula I wherein m, Ar, R1 and R2 are as defined herein. The compounds prepared by the method of the invention are useful as monoamine reuptake inhibitors useful for treatment of CNS indications.

La présente invention se rapporte à un procédé qui consiste : à hydrogéner un composé propionamide indole représenté par la formule h avec du vitride, afin de former un composé aminopropyle indole représenté par la formule i, dans laquelle m, Ar, R1 et R2 sont tels que définis dans le descriptif de l'invention. Les composés préparés par le procédé selon l'invention sont utiles en tant qu'inhibiteurs du recaptage des monoamines pour le traitement de troubles du SNC.

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