C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/00 (2006.01) C07D 241/00 (2006.01) C07D 317/00 (2006.01) C07D 333/02 (2006.01)
Patent
CA 2606410
Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of felbamate, including fluorofelbamate) via reduction of malonate compounds, followed by carbamoylation. Reduction of the malonate compounds is carried out using an electrophilic hydride reagent.
L'invention concerne un procédé de production de 2-halo-1,3-propanediols 2-substitués par réduction de composés de malonate correspondants. Cette invention concerne également un procédé de production de composés de 2-halo-1,3-dicarbamate 2-substitué (tels que des dérivés halo de felbamate, y compris le fluorofelbamate) par réduction de composés de malonate, puis par carbamoylation. La réduction de composés de malonate est effectuée au moyen d'un hydrure réactif électrophile.
Andersen Marc W.
Dotse Anthony K.
He Weixuan
Li Jie
Mortko Henry
Mbm Intellectual Property Law Llp
Medpointe Healthcare Inc.
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