Methods for synthesizing kotalanol and stereoisomers and...

C - Chemistry – Metallurgy – 07 – D

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C07D 333/46 (2006.01) A61K 31/33 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61P 31/10 (2006.01) C07C 31/18 (2006.01) C07D 207/12 (2006.01) C07D 319/06 (2006.01) C07D 327/10 (2006.01) C07D 345/00 (2006.01) C07D 407/04 (2006.01) C07D 407/06 (2006.01) C07D 497/04 (2006.01)

Patent

CA 2756800

Compounds having the general formula (I): wherein X is S, Se or NH, and stereoisomers thereof, and de-O-sulfonated analogues of all of the foregoing, but excluding naturally occurring kotalanol and de-O-sulfonated kotalanol, and methods for synthesizing same. The compounds are useful as glycosidase inhibitors, and may be used in the treatment of diabetes. The synthetic compounds may also be used as standards in the calibration or grading of natural or herbal remedies produced from natural sources of glycosidase inhibitors such as kotalanol.

L'invention porte sur des composés représentés par la formule générale (I) : dans laquelle X représente S, Se ou NH, et sur les stéréo-isomères de ceux-ci et sur les analogues dé-O-sulfonés de tous les composés susdits, mais à l'exclusion du kotalanol et du kotalanol dé-O-sulfoné d'origine naturelle. L'invention porte également sur des procédés pour la synthèse de ceux-ci. Les composés sont utiles comme inhibiteurs de glycosidase et peuvent être utilisés dans le traitement du diabète. Les composés synthétiques peuvent également être utilisés comme étalons dans l'étalonnage ou la classification de remèdes naturels ou à base de plantes produits à partir de sources naturelles d'inhibiteurs de glycosidase tels que le kotalanol.

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