Methods for systematic control of protein stability

Details Methods for systematic control of protein stability Methods for systematic control of protein stability

C - Chemistry, Metallurgy

40

B

C40B 10/00 (2006.01) G06F 19/16 (2011.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C40B 40/10 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2729899

Methods and compositions to control the stability of proteins with special emphasis on antibodies and proteins with antibody-like structures, e.g., having an "immunoglobulin-like" fold, are described. Controlling the stability facilitates differ-ent applications for a protein with the same function, but different stability.

L'invention porte sur des procédés et des compositions pour réguler la stabilité de protéines avec un accent spécial sur les anticorps et les protéines dotées de structures de type anticorps, présentant, par exemple, un repliement « de type immunoglobuline ». Réguler la stabilité facilite différentes applications faisant intervenir une protéine dont la fonction est identique mais la stabilité différente.

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