Methods for targeted expression of therapeutic nucleic acid

Details Methods for targeted expression of therapeutic nucleic acid Methods for targeted expression of therapeutic nucleic acid

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2460095

Expression vectors that include a pre-selected therapeutic nucleic acid operably linked to a tumor specific or cell type-speci fic promoter and a Tcf- 4.beta.-catenin enhancer are provided. The therapeutic nucleic acid preferably includes a gene encoding a therapeutic protein for treatment of, for example, cancer. Methods for targeted expression of therapeutic nucleic acid, and methods for treating cancer, utilizing the expression vectors described herein, are also provided. Host cells are also provided that have been transformed with the expression vectors described herein.

L'invention porte sur des vecteurs d'expression comprenant un acide nucléique présélectionné lié de manière fonctionnelle à une tumeur spécifique ou à un promoteur spécifique de type cellule et un activateur de transcription de la Tcf-4.beta.-caténine. L'acide nucléique thérapeutique comprend un gène codant une protéine thérapeutique utile dans le traitement du cancer, par exemple,. L'invention porte égalemtn sur des procédés d'expression ciblée de l'acide nucléique thérapeutique et sur des procédés de traitement du cancer utilisant les vecteurs d'expression précités. L'invention porte également sur des cellules hôtes qui ont été transformées par les vecteurs d'expression précités.

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