C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2481339
Among the different intrastrand quadruplex structures that can arise from duplex DNA, it has been discovered that a chair conformation is biologically significant. Also, it has been determined that certain mutations in quadruplex forming nucleotide sequences destabilize quadruplex structure and are associated with cancer. Thus, provided herein are quadruplex~destabilized nucleic acid acids, cancer diagnostics and prognostics, methods for using the cancer diagnostics and prognostics to prevent and/or treat cancer, nucleic acid therapeutics that target quadruplex-destabilized nucleotide sequences and methods, methods for identifying compounds that modulate the biological activity of a native quadruplex DNA in a chair conformation, and methods for modulating the biological activity of a native quadruplex DNA with a compound identified by the methods described herein.
Parmi les différentes structures quadruplex intra-brin pouvant provenir d'ADN duplex, une conformation de type chaise possède un intérêt biologique. Par ailleurs, certaines mutations dans des séquences nucléotidiques formant des structures quadruplex déstabilisent la structure quadruplex et sont associées au cancer. L'invention concerne des acides nucléiques à structure quadruplex déstabilisée, des agents de diagnostic et de pronostic du cancer, des procédés d'utilisation de ces agents de diagnostic et de pronostic du cancer destinés à la prévention et/ou au traitement du cancer, des agents thérapeutiques d'acides nucléiques et des procédés de ciblage de séquences nucléotidiques à structure quadruplex déstabilisée, des procédés d'identification de composés modulant l'activité biologique d'un ADN quadruplex endogène en conformation de type chaise, et des procédés de modulation de l'activité biologique d'un ADN quadruplex endogène à l'aide d'un composé selon l'invention.
Bearss David J.
Farrell Thomas J.
Grand Cory L.
Hurley Laurence H.
Siddiqui-Jain Adam
Cyclene Pharmaceuticals Inc.
Cylene Pharmaceuticals Inc.
Cyternex Inc.
Fetherstonhaugh & Co.
The Arizona Board Of Regents On Behalf Of The University Of Ariz
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