Methods for targeting rna molecules

Details Methods for targeting rna molecules Methods for targeting rna molecules

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01) A61P 21/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C12N 15/09 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2363077

Described are methods for identifying targets in RNA molecules based an differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.

L'invention concerne des méthodes qui permettent d'identifier des cibles dans les molécules d'ARN en se basant sur les différences au sein de la structure secondaire de l'ARN par rapport à des variances de séquence entre différentes formes alléliques; des méthodes qui permettent d'identifier ou de développer des petites molécules pouvant être utilisées pour moduler un ARN cible par création de complexes protéine-petite molécule-ARN; des compositions qui renferment lesdites petites molécules; et des méthodes qui permettent d'utiliser lesdites petites molécules et compositions.

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