Methods for the classification and diagnosis of scoliosis

Details Methods for the classification and diagnosis of scoliosis Methods for the classification and diagnosis of scoliosis

G - Physics

01

N

G01N 33/567 (2006.01) C12Q 1/00 (2006.01) G01N 27/02 (2006.01)

Patent

CA 2738840

Methods for diagnosing a predisposition to developing a scoliosis (e g, adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protem-coupled receptor activity are described The methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand If the impedance is higher in the presence of the test compound when compared to in the absence of the test compound, then the test compound is useful in treating the scoliosis.

L'invention porte sur des procédés de diagnostic d'une prédisposition à développer une scoliose (par exemple, scoliose idiopathique adolescente (AIS)) et d'identification de composés de traitement d'une scoliose en se basant sur la modulation de l'activité d'un récepteur couplé à une protéine Gi. Les procédés mettent en jeu la mesure d'une modification de signaux d'impédance de cellules exprimant un récepteur couplé à une protéine Gi avec un ligand. Pour identifier des composés utiles dans le traitement, on met la cellule en contact avec un composé de test et un ligand. Si l'impédance est supérieure en présence du composé de test par comparaison avec l'impédance en l'absence du composé de test, le composé de test est utile pour le traitement de la scoliose.

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