C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01)
Patent
CA 2416584
As disclosed herein, the present invention is directed to unique gene cassettes, and methods for their use, wherein the gene cassettes comprise multifunctional transgenic DNA sequences that completely, or nearly completely, excise themselves from the genome of plants into which they are introduced. The excision process is triggered in response to specific internal or external stimuli by means of excision/recombinase systems in unique combinations and orientations within the multifunctional transgenic sequences. Complete, or nearly complete, removal of the heterologous DNA significantly reduces the possibility of uncontrolled propagation of the transgenic species and may, more importantly, permit crops produced from transgenic plants to be co-mingled with non-transgenic crops for marketing purposes.
La présente invention concerne des cassettes de gènes uniques, ainsi que leurs méthodes d'utilisation. Ces cassettes de gènes contiennent des séquences d'ADN transgéniques multifonctionnelles qui se détachent complètement, ou presque complètement, du génome des plantes dans lesquelles elles sont introduites. L'opération d'excision se déclenche en réponse à des stimuli spécifiques internes ou externes, au moyen de système d'excision/recombinase, selon des combinaisons et des orientations uniques dans les séquences transgéniques multifonctionnelles. L'ablation complète ou quasi-complète de l'ADN hétérologue réduit considérablement le risque de propagation non contrôlée d'espèces transgéniques et peut, avant tout, permettre de mélanger des plantes obtenues à partir de plantes transgéniques avec des plantes non transgéniques à des fins commerciales.
Duan Hui
Li Yi
Mcavoy Richard
O'donnell Colum P.
Wu Yan Hong
Ridout & Maybee Llp
University Of Connecticut
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