Methods for the detection of fatty-acylated proteins

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/02 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2752241

Sensitive, non-radioactive fatty-acyls of Formula I are useful in in vivo methods for detection and cellular imaging of a fatty-acylated substrate (e.g., protein or polypeptide). In Formula I the symbols X and A, and the subscript n are as described herein. These fatty-acyl compounds are can be used, inter alia, for analyzing the lipid composition of proteins in different biological states under various cellular conditions, and serve as a gateway into global lipidomic analysis of cellular proteins.

L'invention porte sur des acyles gras non radioactifs, sensibles, de formule I qui sont utiles dans des procédés in vivo pour la détection d'une imagerie cellulaire d'un substrat à chaînes acyles grasses (par exemple, protéine ou polypeptide). Dans la formule I, les symboles X et A et l'indice n sont tels que décrits présentement. Ces composés à chaînes acyles grasses peuvent être utilisés, entre autres, pour analyser la composition en lipides de protéines dans différents états biologiques sous diverses conditions cellulaires, et servent de passerelle dans l'analyse lipidomique globale de protéines cellulaires.

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