Methods for the diagnosis and treatment of tumors employing...

Details Methods for the diagnosis and treatment of tumors employing... Methods for the diagnosis and treatment of tumors employing...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2438433

There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the hepsin gene, which are amplified ovarian, and/or breast, and/or lung cancer genes. The hepsin gene, its expressed protein products and antibodies are used diagnostically or as targets for cancer therapy; they are also used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.

L'invention se rapporte à des méthodes et à des compositions permettant le diagnostic, la prévention et le traitement de tumeurs et de cancers chez des mammifères, par exemple des sujets humains, au moyen du gène de l'hepsine, qui est un gène amplifié du cancer des ovaires et/ou de la prostate et/ou du sein et/ou du poumon. Le gène de l'hepsine, ses produits protéiques exprimés et ses anticorps sont utilisés pour le diagnostic ou en tant que cibles en thérapie anticancéreuse, ainsi que pour identifier des composés et des réactifs pouvant servir au diagnostic, à la prévention et au traitement d'un cancer.

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