Methods for the diagnosis of dementia and other neurological...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/09 (2006.01) G01N 27/00 (2006.01) G01N 33/483 (2006.01) G01N 37/00 (2006.01)

Patent

CA 2640748

The present invention is directed to a method for differentially diagnosing dementia or the risk of dementia in a patient. The method comprises obtaining a sample from the patient; analyzing the sample to obtain quantifying data for one or more than one metabolite marker; comparing the quantifying data for the one or more than one metabolite marker to corresponding data obtained from one or more than one reference sample; and using the comparison to differentially diagnose dementia or the risk of dementia. The method may also assis in assessing dementia or the risk of dementia in a patient. The present invention is also directed to metabolite markers and compounds useful in the present method.

Cette invention concerne une méthode de diagnostic différentiel de la démence ou du risque de démence chez un patient. Cette méthode consiste à prélever un échantillon sur un patient; à analyser l'échantillon pour obtenir des données quantitatives pour un ou plusieurs marqueurs de métabolites; à comparer les données quantitatives pour le ou les marqueurs de métabolites à des données correspondantes obtenues à partir d'un ou plusieurs échantillons de référence; et à utiliser la comparaison pour établir le diagnostic différentiel de la démence ou du risque de démence. Cette méthode peut également contribuer à évaluer la démence ou le risque de démence chez un patient. Cette invention concerne en outre des marqueurs de métabolites et des composés intervenant dans cette méthode.

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