C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/88 (2006.01) G01N 33/564 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2155677
A method for detecting a autoantibodies to glutamic acid decarboxylase (GAD) in the serum of a patient as diagnostic of a diabetic or prediabetic condition in the patient, comprises contacting a serum sample from the patient with a GAD antigen and detecting binding of autoantibodies to GAD in the sample by the GAD antigen, wherein the GAD antigen comprises a GAD preparation containing an enhanced amount of dimer(s) or oligomer(s) of the 65 kD and/or 67 kD isoforms of GAD. A diagnostic kit is also disclosed.
Mackay Ian Reay
Rowley Merrill Joy
Zimmet Paul Zev
Kirby Eades Gale Baker
Monash University
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