Methods for the diagnosis of ovarian cancer health states...

G - Physics – 01 – N

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G01N 33/49 (2006.01) G01N 27/00 (2006.01) H01J 49/26 (2006.01)

Patent

CA 2676109

The present invention describes a method for predicting a health-state indicative of the presence of ovarian cancer (OC). The method measures the intensities of specific small organic molecules, called metabolites, in a blood sample from a patient with an undetermined health-state, and compares these intensities to those observed in a population of healthy individuals and/or to the intensities previously observed in a population of confirmed ovarian cancer-positive individuals. Specifically, the present invention relates to the diagnosis of OC through the measurement of vitamin E isoforms and related metabolites. The method enables a practitioner to determine the probability that a screened patient is positive or at risk for ovarian cancer.

La présente invention concerne un procédé permettant de prédire un état de santé signe de la présence d'un cancer des ovaires. Le procédé consiste à mesurer les intensités de petites molécules organiques spécifique ou métabolites dans un échantillon de sang d'une patiente présentant un état de santé indéterminé, et à comparer ces intensités à celles observées dans une population d'individus sains et/ou à celles préalablement observées dans une population d'individus dont le cancer des ovaires est confirmé. L'invention concerne plus particulièrement le diagnostic du cancer des ovaires par une mesure d'isoformes de la vitamine E et des métabolites correspondants. Le procédé permet au praticien de déterminer la probabilité que présente une patiente examinée à être positive ou en risque de cancer des ovaires.

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