Methods for the early diagnosis of ovarian cancer

Details Methods for the early diagnosis of ovarian cancer Methods for the early diagnosis of ovarian cancer

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2537115

Protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.

Selon cette invention, la protéase hepsine est spécifiquement surexprimée dans les tumeurs malignes ovariennes et autres tumeurs malignes. Un certain nombre de peptides hepsine peut induire des réponses immunitaires à l'hepsine, ce qui démontre le potentiel de ces peptides dans la surveillance et le développement d'immunothérapies contre les tumeurs malignes ovariennes et autres tumeurs malignes. Cette invention concerne une variante de la protéine hepsine utilisée comme marqueur pour des cellules cancéreuses ovariennes, des cellules cancéreuses prostatiques ou des cellules cancéreuses rénales.

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