C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/16 (2006.01) C07D 277/12 (2006.01) C07D 417/12 (2006.01) C07D 233/28 (2006.01) C07D 263/16 (2006.01) C07D 305/14 (2006.01)
Patent
CA 2314514
The invention relates to a method for preparing an ester, by admixing a compound having structure (I or IV) with a base and an alcohol to produce an ester, wherein the alcohol is a precursor to Taxol.TM. and its analogs. The present invention also relates to compounds having structure (I and IV) and methods of making them therefor. The invention also relates to the esterification of an alcohol by adding an alkoxide to a compound having structure (VII). The invention further relates to compounds having structure (I, IV, and VII) and methods of making them therefor. The invention further relates to alcohols, and, in particular, alcohols that are synthetic precursors to Taxol.TM. and analogs thereof.
L'invention concerne un procédé de préparation d'un ester, par mélange d'un composé de la structure (I) ou (IV) avec une base et un alcool pour produire un ester, l'alcool étant un précurseur de Taxol et de ses analogues. La présente invention concerne également des composés présentant la structure (I) et (IV), ainsi que leurs procédés de production. L'invention concerne en outre l'estérification d'un alcool par adjonction d'un alcoxyde à un composé de la structure (VII). L'invention concerne aussi des composés de la structure (I), (IV) et (VII) et leurs procédés de production. L'invention concerne enfin des alcools, et notamment des alcools qui sont des précurseurs synthétiques de Taxol et de ses analogues.
Captain Laura
Liotta Dennis C.
Schestopol Marcus A.
Snyder James P.
Venkatesan Hariharan
Emory University
Gowling Lafleur Henderson Llp
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