G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) A61K 45/00 (2006.01) C07K 1/14 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 1/02 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 23/207 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2484115
The present invention is drawn to methods of characterization of the properties and functions of SV2 proteins. The invention further includes methods of identifying compounds or agents which modulate the activity of SV2 proteins. Included in these methods is the identification of compounds or agents which modulate the binding of levetiracetam to SV2 proteins, including SV2A. Additionally, the present invention provides biotinylated ligands as a tool to screen chemical libraries and characterize the SV2 proteins. Further, the present invention provides a method of solubilizing and purifying functionally active membrane associated proteins, such as SV2.
La présente invention concerne des procédés de caractérisation des propriétés et fonctions des protéines SV2. L'invention concerne également des procédés d'identification de composés ou agents qui modulent l'activité des protéines SV2. Ces procédés comportent l'identification des composés ou agents qui modulent la liaison de lévétiracétam aux protéines SV2, y compris aux protéines SV2A. De plus, la présente invention comme l'utilisation de ligands biotinylés comme outil de criblage de librairies chimiques et de caractérisation des protéines SV2. La présente invention concerne également la solubilisation et la purification des protéines associées à la membrane fonctionnellement active, telles que les protéines SV2.
Fuks Bruno
Lynch Berkley
Nocka Karl
Robic
Ucb S.a.
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