Methods for the identification of all-antigens and their use...

Details Methods for the identification of all-antigens and their use... Methods for the identification of all-antigens and their use...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 35/12 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/28 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 30/02 (2006.01) G01N 33/68 (2006.01) C07K 14/74 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2489296

The present invention delivers a new concept with respect to the broad definition of alto-antigens that drive graft-versus~tumor (GVT) reactions and/ or graft-versus-host disease (GVHD). The new method for the identification of allo-antigens, which has so far been an unresolved technical problem, furthermore calls for new strategies in immunotherapy. Because the analysis of HLA-binding proteins can now be done with alloantigens for which the corresponding amino~acid sequence is known, the present invention also allows the separation of alto-reactive T cells that only recognize tumor cells from those that mediate GVHD. Antigens defined with the new technology are especially useful for diagnosis and vaccination in cancer and transplantation- related diseases.

La pr~sente invention repose sur un nouveau concept relatif ~ la d~finition large d'allo-antig­nes entra¹nant des r~actions antitumorales (GVT) et/ou des r~actions de greffe contre hÙte (GVHD).Le nouveau proc~d~ d'identification d'allo-antig­nes, qui jusqu'~ pr~sent repr~sentait un probl­me technique non r~solu, ouvre en outre une voie pour de nouvelles strat~gies d'immunoth~rapie. Etant donn~ que l'on peut maintenant effectuer une analyse des prot~ines de liaison HLA avec des allo-antig­nes pour lesquels la s~quence d'acides amin~s correspondante est connue, l'invention permet ~galement de s~parer les lymphocytes T allor~actifs qui ne reconnaissent que les cellules canc~reuses de ceux qui agissent comme m~diateurs de la r~action greffe contre hÙte. Les antig­nes d~finis selon le nouveau proc~d~ de l'invention sont particuli­rement utiles pour le diagnostic et la vaccination dans les maladies canc~reuses et li~es aux transplantations.

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