Methods for the in vivo measurement of the concentration of...

A - Human Necessities – 61 – K

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A61K 49/00 (2006.01) A61K 49/06 (2006.01) G01R 33/28 (2006.01) G01R 33/465 (2006.01)

Patent

CA 2119345

Methods wherein the concentration of NMR-detectable xenobiotic compounds may be determined in living subjects by in vivo measurement of one or more magnetic resonance signals. In preferred embodiments, the present invention provides a method for evaluating, in vivo, the clearance rate of a xenobiotic compound from a living subject, thereby providing a noninvasive method for determining the status of the excretory organs of the subject, and a method for determining the proper dosing regimen of a pharmacologically active compound to be administered to the subject.

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