Methods for the manufacture of amorphous cefuroxime axetil

Details Methods for the manufacture of amorphous cefuroxime axetil Methods for the manufacture of amorphous cefuroxime axetil

C - Chemistry, Metallurgy

07

D

C07D 501/34 (2006.01) C07D 501/00 (2006.01) C07D 501/12 (2006.01)

Patent

CA 2211499

A process for preparing pure amorphous cefuroxime axetil comprising the steps of dissolving crystalline cefuroxime axetil in a highly polar organic solvent and adding the resulting solution to water, or alternatively, dissolving crystallinecefuroxime axetil in a highly polar solvent and adding small quantities of waterto the organic solution and adding the resulting organic-aqueous solution to water.

Un procédé pour préparer du céfuroxime axétil amorphe pur comprenant les étapes suivantes : dissoudre le céfuroxime axétil cristallin dans un solvant organique hautement polaire et ajouter la solution ainsi obtenue dans de l'eau, ou encore, dissoudre le céfuroxime axétil cristallin dans un solvant hautement polaire et ajouter de petites quantités d'eau à la solution organique et ajouter la solution organique aqueuse ainsi obtenue dans de l'eau.

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