Methods for the prediction of suicidality during treatment

Details Methods for the prediction of suicidality during treatment Methods for the prediction of suicidality during treatment

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2516484

This invention provides methods to predict the likelihood of suicidal or self- destructive behavior in a patient during treatment. The method employs the detection of a polymorphism in the SLC6A3 gene at Exon 9 A59G or a surrogate marker, by various methods. Also provided are methods of treatment based on the presence or absence of this polymorphism or surrogate marker. Also provided are kits to use in the methods of the invention.

L'invention concerne des procédés permettant de prédire la probabilité d'un comportement suicidaire ou autodestructeur chez un patient pendant un traitement. Ce procédé consiste à détecter un polymorphisme dans le gène SLC6A3 au niveau de l'exon 9 A59G ou un marqueur de substitution, par divers procédés. L'invention concerne également des procédés de traitement fondés sur la présence ou l'absence de ce polymorphisme ou du marqueur de substitution. L'invention concerne en outre des kits à utiliser dans lesdits procédés.

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