Methods for the preparation of a fine chemical by fermentation

Details Methods for the preparation of a fine chemical by fermentation Methods for the preparation of a fine chemical by fermentation

C - Chemistry, Metallurgy

12

P

C12P 13/08 (2006.01) C12N 1/21 (2006.01) C12N 9/04 (2006.01) C12N 15/53 (2006.01)

Patent

CA 2548125

The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

La présente invention concerne des procédés permettant d'accroître la production d'un produit chimique fin tel que la lysine dans un micro-organisme, par exemple l'espèce Corynebacterium, par la dérégulation d'un gène codant une enzyme, la lactate déshydrogénase. Dans un mode de réalisation préféré, l'invention concerne des procédés permettant d'accroître la production de la lysine dans l'espèce Corynebacterium glutamicum par augmentation de l'expression de l'activité de la lactate déshydrogénase. L'invention prévoit en outre un nouveau procédé de production de la lysine par régulation du flux de carbone vers l'oxaloacétate (OAA). Dans un mode de réalisation préféré, des procédés de production de la lysine sont décrits, ces procédés comprenant l'utilisation du fructose ou du saccharose comme source de carbone.

Affiliated with

Also associated with

Rating

Methods for the preparation of a fine chemical by fermentation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the preparation of a fine chemical by fermentation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the preparation of a fine chemical by fermentation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1429119