Methods for the preparation of a fine chemical by fermentation

Details Methods for the preparation of a fine chemical by fermentation Methods for the preparation of a fine chemical by fermentation

C - Chemistry, Metallurgy

12

P

C12P 13/08 (2006.01) C12N 1/21 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2546847

The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i, e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

La présente invention concerne des méthodes qui permettent d'augmenter la production d'un produit chimique fin, tel que la lysine provenant d'un micro-organisme comme Corynebacterium, par dérégulation d'un gène codant une enzyme, la glycérol-kinase. Dans un mode de réalisation préféré, on décrit des méthodes qui permettent d'augmenter la production de la lysine chez l'espèce Corynebacterium glutamicum,par intensification de l'expression de l'activité de la glycérol-kinase. L'invention concerne en outre une nouvelle méthode de production de la lysine par régulation du flux de carbone vers l'oxaloacétate (OAA). Dans un mode de réalisation préféré, on décrit des méthodes de production de la lysine qui utilisent la fructose ou le saccharose comme source de carbone.

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