Methods for the preparation of biphenyl isoxazole sulfonamides

Details Methods for the preparation of biphenyl isoxazole sulfonamides Methods for the preparation of biphenyl isoxazole sulfonamides

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) C07D 261/16 (2006.01) C07D 413/12 (2006.01) C07F 5/04 (2006.01)

Patent

CA 2425911

Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.

L'invention concerne des procédés de préparation de sulfonamides de biphényl-isoxazole et de leurs produits intermédiaires. La présente invention concerne également de nouveaux produits intermédiaires préparés selon ces procédés. Les sulfonamides de biphényl-isoxazole préparés selon les procédés de la présente invention sont des antagonistes de l'endothéline utiles, notamment, dans le traitement de l'hypertension.

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