Methods for the preparation of biphenyl isoxazole sulfonamides

Details Methods for the preparation of biphenyl isoxazole sulfonamides Methods for the preparation of biphenyl isoxazole sulfonamides

C - Chemistry, Metallurgy

07

C

C07C 15/12 (2006.01) C07C 15/14 (2006.01) C07C 25/02 (2006.01) C07C 233/64 (2006.01) C07C 233/65 (2006.01) C07C 233/68 (2006.01) C07C 233/73 (2006.01) C07C 235/02 (2006.01) C07C 235/42 (2006.01) C07C 235/48 (2006.01) C07C 303/22 (2006.01) C07C 303/36 (2006.01) C07C 303/38 (2006.01) C07C 309/63 (2006.01) C07C 309/64 (2006.01) C07C 309/65 (2006.01) C07C 309/72 (2006.01) C07C 309/73 (2006.01) C07C 311/15 (2006.01) C07C 311/20 (2006.01) C07D 207/02 (2006.01) C07D 207/32 (2006.01) C07D 207/34 (2006.01) C07D 207/

Patent

CA 2367916

Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension, congestive heart failure and male erectile dysfunction.

L'invention concerne des procédés pour la préparation de diphénylisoxazolesulfonamides et leurs intermédiaires. L'invention concerne aussi de nouveaux intermédiaires préparés selon ces procédés. Les diphénylisoxazolesulfonamides ainsi obtenus sont des antagonistes de l'endothéline utiles, notamment, pour le traitement de l'hypertension, de l'insuffisance cardiaque globale et des troubles de l'érection chez l'homme.

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