C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/329, 260/361
C07D 333/20 (2006.01) C07D 213/32 (2006.01) C07D 307/46 (2006.01) C07D 333/16 (2006.01) C07D 333/18 (2006.01)
Patent
CA 1055948
ABSTRACT OF THE DISCLOSURE Processes are provided for the preparation of a series of new compounds, their pharmaceutically acceptable, non-toxic salts, and their pharmaceutically acceptable, non-toxic esters, which compounds are valuable in the human and veterinary practice. Such compounds have the general formula: Image in which R1 represents a straight or branched unsubstituted alkyl containing 1 to 6 carbon atoms; a straight or branched unsubstituted alkenyl containing 2 to 6 carbon atoms; a straight or branched unsubstituted alkynyl containing 2 to 6 carbon atoms; or a methyl or ethyl radical substituted with phenyl, furyl, thienyl or pyridyl radical; Ar stands for a phenyl radical; Y stands for O, S, NH or a CH2 radical; YR1 is placed in the 2- or 3-position; or the pharmaceutically acceptable, non-toxic salts thereof; or the pharmaceutically acceptable, non-toxic esters thereof, with cyano methanol, benzyl alcohol or C1 - 66 alkanols. The compounds of an aspect of the invention which are valuable in the human and veterinary practice possess a pronounced diuretic and/or saluretic activity.
208192
Bruun Herta
Feit Peter W.
Nielsen Ole B.t.
Leo Pharmaceutical Products Ltd. A/s (lovens Kemiske Fabrik Prod
Na
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