C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/53 (2006.01) C07D 207/50 (2006.01)
Patent
CA 2505365
Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
L'invention concerne des procédés pour la préparation de composés pharmaceutiques inhibant des kinases de formule (I) ou d'un sel ou solvate pharmaceutiquement acceptable de ces composés, R¿1? à R¿6? et Z ayant la signification indiquée dans la description. Les procédés selon l'invention utilisent un processus d'amination dans lequel on fait réagir un pyrrole avec une haloamine, de préférence de la chloramine. Cette étape est suivie par une cyclisation afin de former un noyau pyrrolotriazine.
Doubleday Wendel William
Dyckman Alaric J.
Godfrey Jollie Duaine Jr.
Grosso John A.
Hynes John Jr.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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