Methods for the preparation of stereoisomerically enriched...

Details Methods for the preparation of stereoisomerically enriched... Methods for the preparation of stereoisomerically enriched...

C - Chemistry, Metallurgy

07

D

C07D 207/00 (2006.01)

Patent

CA 2549289

The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkenyl,-(CR7R8)t(C6-C14 aryl), and -(CR7R8)t(4-10 membered heterocyclic), and wherein said C6-C14 aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C1-C10 alkyl, -OR7, and -N(R7R8), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.

L'invention concerne des procédés pour la préparation d'un composé stéréoisomériquement enrichi de formule (I), R?6¿ étant hydrogène, consistant à traiter un composé de formule (I), R?6¿ étant choisi parmi C¿1?-C¿10? alkyle, C¿2?-C¿10? alcényle, C¿2?-C¿10? alcynyle,-(CR?7¿R?8¿)¿t?(C¿6?-C¿14? aryle), et -(CR?7¿R?8¿)¿t?(hétérocyclique à 4-10 chaînons), et lesdits C¿6?-C¿14 ?aryle et hétérocyclique à 4-10 chaînons étant éventuellement substitués par au moins un substituant choisi parmi halo, C¿1?-C¿10? alkyle, -OR?7¿, et -N(R?7¿R?8¿), avec un biocatalyseur dans une solution aqueuse, un solvant organique, ou un mélange de solvants organique et aqueux, au moins un stéréoisomère étant sélectivement hydrolysé.

Affiliated with

Also associated with

Rating

Methods for the preparation of stereoisomerically enriched... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the preparation of stereoisomerically enriched..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the preparation of stereoisomerically enriched... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1593536