Methods for the prevention and treatment of infections using...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 35/16 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) A61K 47/48 (2006.01) C07K 16/12 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2400488

The present invention relates to the treatment and prevention of viral infections, microbial infections, and septic shock by the administration of anti-C3b(i) antibodies. The present invention also relates to methods of treating and preventing viral infection, microbial infection, or septic shock in an animal comprising administering to said animal IgG antibodies, IgM antibodies and/or complement components in combination with antibodies immunospecific for C3b(i). The present invention also relates methods of treating and preventing viral infection or microbial infection in an animal comprising administrating said animal antibodies that immunospecifically bind to one or more viral antigens or microbial antigens, respectively, in combination with antibodies immunospecific for C3b(i). The present invention further relates methods of treating and preventing septic shock in an animal comprising administrating said animal antibodies that immunospecifically bind to lipopolysaccharide, an endotoxin or a constituent of the outer wall of a gram negative bacteria in combination with antibodies immunospecific for C3b(i).

La présente invention concerne le traitement et la prévention d'infections virales, et de chocs septiques par administration d'anticorps anti-C3b(i). Cette invention concerne également des procédés destinés au traitement et à la prévention d'infections virales, d'infections microbiennes ou de chocs sceptiques chez un animal qui consistent à administrer à cet animal des anticorps IgG, des anticorps IgM et/ou des composants du complément en combinaison avec des anticorps immunospécifiques aux C3b(i). L'invention concerne en outre des procédés destinés au traitement et à la prévention d'infections virales ou d'infections microbiennes chez un animal qui consistent à administrer à cet animal des anticorps qui se lient de façon immunospécifique à un ou plusieurs antigènes viraux ou microbiens, respectivement, en combinaison avec des anticorps immunospécifiques aux C3b(i). L'invention concerne enfin des procédés destinés au traitement et à la prévention de chocs sceptiques chez un animal qui consistent à administrer à cet animal des anticorps qui se lient de façon immunospécifique au lipopolysaccharide, une endotoxine ou un constituant de la paroi extérieure d'une bactérie gram négatif en combinaison avec des anticorps immunospécifiques aux C3b(i).

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