Methods for the production of ips cells using non-viral...

Details Methods for the production of ips cells using non-viral... Methods for the production of ips cells using non-viral...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C12N 5/071 (2010.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2726990

Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For ex-ample, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.

L'invention concerne des procédés et une composition dinduction de cellules souches pluripotentes et dautres types cellulaires souhaités. Par exemple, dans certains aspects, l'invention concerne des procédés pour générer des cellules souches pluripotentes induites essentiellement sans vecteur. En outre, linvention concerne des cellules souches pluripotentes induites et des types cellulaires souhaités essentiellement exempts déléments de vecteurs exogènes avec les vecteurs d'expression épisomiques pour exprimer des facteurs de programmation de différenciation.

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