Methods for the production of polymer carrier materials...

C - Chemistry – Metallurgy – 08 – J

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C08J 9/00 (2006.01) B01D 15/08 (2006.01) C07K 1/04 (2006.01) C08F 20/58 (2006.01)

Patent

CA 2572142

The invention relates to methods for the production of polymer carrier materials for solid phase synthesis, particularly for peptide synthesis. (Meth)acrylamide derivatives based on carbon hydrates, which can also contain other protective groups, are polymerized by means of suspension polymerization in an aqueous phase, optionally with the addition of pore-forming additives, and subsequently the protective groups are fully or partially cleaved. It is thus possible to obtain polymer carriers whose morphology (particle size, porosity), degree of cross-linking and swelling capability in aqueous and organic media can be adjusted in a targeted manner and whose reactive groups offer multiple opportunities for the immobilization of anchor groups and protective groups. The hydroxyl groups of the polymer carrier can be activated according to usual methods of solid phase synthesis.

L'invention concernant un procédé de production de matériaux supports polymères destinés à la synthèse en face solide, notamment à la synthèse de peptides. A cet effet, on polymérise des dérivés de (méth)acrylamide à base d'hydrates de carbone, pouvant également contenir d'autres groupes de protection, par polymérisation en suspension en phase aqueuse éventuellement avec adjonction d'additifs porogènes puis on effectue la fission totale ou partielle des groupes de protection. On obtient ainsi des supports polymères dont la morphologie (taille de particules, porosité), le degré de réticulation et l'aptitude à l'expansion peuvent être réglés de manière ciblée dans des milieux aqueux et organiques et dont les groupes réactifs offrent de nombreuses possibilités d'immobilisation des groupes d'ancrage et de protection. Les groupes hydroxyle des supports polymères peuvent être activés selon les procédés usuels de la synthèse en phase solide.

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