Methods for the production of sildenafil base and citrate salt

Details Methods for the production of sildenafil base and citrate salt Methods for the production of sildenafil base and citrate salt

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 15/10 (2006.01)

Patent

CA 2552003

Provided are processes for the preparation of sildenafil base and the citrate salt sildenafil. Also provided are sildenafil citrate water adduct and a method of preparing pharmaceutical compositions comprising combining the sildenafil citrate and/or sildenafil citrate water adduct with at least one pharmaceutically-acceptable excipient.

Procédés de préparation de sildénafil base et du sel citrate de sildénafil. La présente invention se rapporte également à l'adduit aqueux du citrate de sildénafil ainsi qu'à un procédé de préparation de compositions pharmaceutiques consistant à combiner le citrate de sildénafil et/ou l'adduit aqueux du citrate de sildénafil avec au moins un excipient pharmaceutiquement acceptable.

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