Methods for the protection of memory and cognition

Details Methods for the protection of memory and cognition Methods for the protection of memory and cognition

A - Human Necessities

01

N

A01N 43/38 (2006.01) A01N 43/36 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) C07D 209/02 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 411/00 (2006.01)

Patent

CA 2527114

The invention features certain compounds useful in the treatment of memory disorders, i.e., they reduce or delay memory loss or they enhance memory retention. Because certain of the compounds do not substantially inhibit either COX-1 or COX-2 at therapeutically relevant doses, these compounds are far less likely to cause gastrointestinal ulceration than is indomethacin, which is known to inhibit both COX-1 and COX-2. Certain of the compounds inhibit the activity of DAO at therapeutically relevant doses. Among the memory disorders that can be treated are AD, mild cognitive impairment (MCI; a common precursor to AD), and memory loss or cognitive impairment associated with vascular dementias, amnesia, dementia, AIDS dementia, Huntington's Disease, hydrocephalus, depression, Pick's Disease, Creutzfeldt-Jakob Syndrome, electroconvulsive therapy, or Parkinson's Disease.

L'invention concerne certains composés utiles dans le traitement des troubles de la mémoire; par exemple, ils limitent ou inhibent la perte de mémoire ou améliorent la rétention dans la mémoire. Du fait que certains de ces composés n'inhibent pas sensiblement COX-1 ou COX-2 à des doses appropriées du point de vue thérapeutique, ces composés risquent beaucoup moins de provoquer l'ulcération gastro-intestinale que l'indométhacine dont on connaît la capacité d'inhiber COX-1 et COX-2. Certains de ces composés inhibent l'activité de DAO à des doses appropriées du point de vue thérapeutique. Parmi les troubles de mémoire qui peuvent être traités sont AD, le trouble léger de la cognition (MCI, un précurseur courant à AD), ou une perte de mémoire ou un handicap cognitif associé à la démence vasculaire, l'amnésie, la démence, la démence due au SIDA, la maladie de Huntington, l'hydrocéphalie, la dépression, la maladie de Pick, le syndrome de Creutzfeldt-Jakob, la thérapie électroconvulsive ou la maladie de Parkinson.

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