Methods for the purification of stable radioiodine conjugates

Details Methods for the purification of stable radioiodine conjugates Methods for the purification of stable radioiodine conjugates

A - Human Necessities

61

K

A61K 51/08 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2515088

The present invention is directed toward a method for preparing and purifying a conjugate of a radioiodinated aminopolycarboxylate-appended peptide and a targeting M agent. The method involves (A) providing a solution comprising (i) unbound radioiodine (ii) a radioiodinated aminopolycarboxylate-appended peptide that is not conjugated to a targeting agent (iii) and a radioiodinated aminopolycarboxylate-appended peptide that is conjugated to the targeting agent; (B) contacting the solution with an anion-exchange resin; and (C) passing the anion-exchange resin and solution together through a filter capable of trapping anion-exchange resin particles.

La présente invention concerne un procédé pour préparer et purifier un conjugué d'un peptide à aminopolycarboxylate annexé et iode radioactif et d'un agent de ciblage. Le procédé comprend: (A) la mise à disposition d'une solution comprenant (i) de l'iode radioactif non lié, (ii) un peptide à aminopolycarboxylate annexé et iode radioactif qui n'est pas conjugué à un agent de ciblage, et (iii) un peptide à aminopolycarboxylate annexé et iode radioactif qui est conjugué à l'agent de ciblage; (B) la mise en présence de la solution avec une résine échangeuse d'anions; et (C) le passage simultané de la résine échangeuse d'anions et de la solution par un filtre capable de piéger les particules de résine échangeuse d'anions.

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