Methods for the recovery of tissue plasminogen activator

Details Methods for the recovery of tissue plasminogen activator Methods for the recovery of tissue plasminogen activator

C - Chemistry, Metallurgy

12

N

195/128, 195/78,

C12N 9/64 (2006.01) C12N 15/58 (2006.01)

Patent

CA 1333163

A method for recovering t-PA from a liquid medium is disclosed. The method comprises contacting a liquid medium with at least one substrate capable of effecting a separation of intact t-PA from degraded t-PA thereafter recovering the intact t-PA free from other unrelated protein. The present invention also provides compounds produced by this method, compounds comprising intact one-chain t-PA and pharmaceutical compositions containing them and methods for using such compositions.

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