C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C12N 9/02 (2006.01) C12N 9/99 (2006.01) C12Q 1/02 (2006.01) C12Q 1/32 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2705376
AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH2 into PGF2.alpha.. AKR1B1 as a therapeutic target, and method for modulating its expression and activity are provided. Methods for regulating the expression and activity of PGF2.alpha. are also provided.
Selon l'invention, l'AKR1B1 (EC 1.1.1.21) est une aldose réductase qui a principalement été associée à la voie des polyols et, plus récemment, à la dépéroxydation des lipides. Nous avons découvert que l'activité primaire de cette enzyme est plutôt une activité de PGFS, catalysant la transformation de PGH2 en PGF2a. L'invention propose l'AKR1B1 en tant que cible thérapeutique et un procédé de modulation de son expression et de son activité. L'invention propose également des procédés de régulation de l'expression et de l'activité de PGF2a.
Bresson Eva
Chapdelaine Pierre
Fortier Michel
Madore Eric
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universite Laval
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