Methods for the selection of aptamers

Details Methods for the selection of aptamers Methods for the selection of aptamers

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01)

Patent

CA 2611198

The present invention generally relates to methods for selecting aptamers. More specifically, the invention provides methods for the selection of at least one aptamer for use in combination with another epitope binding agent such as another aptamer, an antibody, or a double stranded nucleic acid. The invention also encompasses methods for simultaneously selecting at least two aptamers that each recognize distinct epitopes on a target molecule.

L'invention concerne de manière générale des procédés de sélection d'aptamères. Elle concerne plus spécifiquement des procédés permettant de sélectionner au moins un aptamère qui s'utilise en combinaison avec un autre agent de liaison d'épitope tel qu'un autre aptamère, un anticorps ou un acide nucléique bicaténaire. L'invention concerne aussi des procédés permettant de sélectionner simultanément au moins deux aptamères reconnaissant chacun des épitopes distincts sur une molécule cible.

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