C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) C07B 61/00 (2006.01) C07D 493/10 (2006.01) C07H 15/26 (2006.01) C07H 19/16 (2006.01) C12Q 1/04 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 21/00 (2006.01) G01N 21/76 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) H04R 25/00 (2006.01)
Patent
CA 2314422
The combinatorial screening assays and detection methods of the present invention encompass highly diversified libraries of compounds which act as fingerprints to allow for the identification of specific molecular differences existing between biological samples. The specific molecular differences identified by the combinatorial screening assay and detection methods of the present invention are potential targets for diagnosis and development therapeutics. The methods of the invention can be used in diagnostics, drug discovery, as well as genomics and proteomics. Figure (1) which is illustrative of the methods of the invention shows the interaction between molecular probes described in Table II and a human serum sample.
L'invention concerne des techniques de criblage combinatoire et de détection portant sur des banques de composants extrêmement diversifiées qui agissent comme empreintes permettant l'identification des différences moléculaires spécifiques existant entre des échantillons biologiques. Les différences moléculaires spécifiques identifiées par la technique de criblage combinatoire et par les techniques de détection représentent des cibles potentielles pour le diagnostic et la mise au point de traitements. On peut utiliser ces techniques pour établir des diagnostics, découvrir des médicaments ainsi que pour déterminer les génomes et les protéines. La figure (1) qui illustre ces techniques montre l'interaction entre les sondes moléculaires décrites dans la table II et un échantillon de sérum humain.
Gao Yun
Heefner Donald L.
Jones Steven W.
Zepp Charles M.
Osler Hoskin & Harcourt Llp
Sepracor Inc.
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