Methods for the stereoselective synthesis and enantiomeric...

Details Methods for the stereoselective synthesis and enantiomeric... Methods for the stereoselective synthesis and enantiomeric...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C12N 9/10 (2006.01) C12P 13/04 (2006.01) C12P 13/22 (2006.01) C12P 41/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2529509

The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of Beta-amino acids. A novel D-Beta- aminotransferase, which exhibits stereoselectivity for D-Beta phenyalanine D-3- amino-3-phenylpropanoic acid, was purified from a newly-isolated strain of Variovorax paradoxus. A novel L-Beta- aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus. The D- and L-Beta- aminotransferases can be used to facilitate the stereoselective biosynthesis of Beta-D-phenylalanine or Beta-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenypropanoic acid in the presence of the cofactor pyridoxal photephate.

L'invention concerne des méthodes de synthèse stéréospécifique et d'enrichissement énantiomère d'acides .beta.-aminés. On a purifié à partir d'une souche nouvellement isolée de Variovorax paradoxus une D-.beta.-aminotransférase nouvelle qui présente une stéréosélectivité pour la D-.beta.-phénylalanine (acide D-3-amino-3-phénylpropinique). On a purifié à partir d'une souche nouvellement isolée d'Alcaligenes eutrophus une L-.beta.-aminotransférase nouvelle. Les D- et L-.beta.-aminotransférases peuvent être utilisées pour faciliter la biosynthèse stéréosélective de la .beta.-D-phénylalanine ou de la .beta.-L-phénylalanine à partir d'un mélange d'acide L-glutamique ou de L-alanine, respectivement, et d'acide 3-keto-3-phénylpropionique en présence du cofacteur phosphate de pyridoxal

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