Methods for the synthesis of monofucosylated...

Details Methods for the synthesis of monofucosylated... Methods for the synthesis of monofucosylated...

C - Chemistry, Metallurgy

12

P

C12P 19/26 (2006.01) A61K 31/70 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07H 3/06 (2006.01) C07H 15/04 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2110997

2110997 9222662 PCTABS00018 Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound .beta.Gal(1-4).beta.GlcNAc(1-3).beta.Gal(1-4).beta.GlcNAc-R. In particular, the methods of this invention provide for a multi-step synthesis wherein selective monofucosylation is accomplished on the 3-hydroxy group on only one of the GlcNAc units found in the .beta.Gal(1-4).beta.GlcNAc(1-3).beta.Gal(1-4).beta.GlcNAc-R compound. In this step, monofucosylation is achieved by use of the .alpha.(1-3)fucosyltransferase.

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