C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2729857
The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoK.beta.) activity as well as to methods for the design of personalized therapies and for determining the response of an agent capable of inducing choline kinase beta (hereinafter ChoK.beta.) for the treatment of cancer as well as to methods for determining the prognosis of a patient based on the determination of the ChoK.beta. expression levels as well as based on the determination of the relationship between the ChoK.beta. and ChoK.alpha. expression levels. Finally, the invention relates to methods for determining the response of a patient who suffers from cancer to ChoK.alpha.-inhibiting agents based on the determination of the PEMT and/or ChoK.beta. expression levels.
La présente invention concerne des méthodes pour le traitement du cancer basées sur l'induction de l'activité choline kinase bêta (ci-après, ChoKß) ainsi que des méthodes pour la conception de thérapies personnalisées et pour déterminer la réponse d'un agent pouvant induire la choline quinase bêta (ci-après, ChoKß) pour le traitement du cancer ainsi que des méthodes pour déterminer le pronostic d'un patient basées sur la détermination des niveaux d'expression de ChoKß ainsi que basées sur la détermination de la relation entre les niveaux d'expression de ChoKß et de ChoKa. Enfin, l'invention concerne des méthodes pour déterminer la réponse d'un patient qui est atteint de cancer à des agents inhibiteurs de ChoKa basées sur la détermination des niveau d'expression de PEMT et/ou de ChoKß.
Gallego Ortega David
Lacal Sanjuan Juan Carlos
Ramirez de Molina Ana
Perry + Currier
Traslational Cancer Drugs Pharma S.l.
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