A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/07 (2006.01) A61P 27/02 (2006.01)
Patent
CA 2714530
A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis- retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
L'invention porte sur un procédé de traitement ou de prévention d'un dysfonctionnement rétinien lié à l'âge. Ce procédé met en jeu l'administration à un patient d'une quantité pharmaceutiquement efficace d'un dérivé rétinien synthétique de manière répétée pendant une durée d'au moins environ 3 mois. Des dérivés rétiniens synthétiques efficaces comprennent des esters 9-cis-rétinyliques, des esters 11-cis-rétinyliques, des dérivés et congénères de ceux-ci, et des combinaisons de ceux-ci. Des substituants d'esters appropriés comprennent des carboxylates d'acides monocarboxyliques en C1-C10 et d'acides polycarboxyliques en C2-C22.
Maeda Tadao
Palczewski Krzysztof
Saperstein David
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Washington
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