Methods for the treatment and prevention of diseases of...

A - Human Necessities – 61 – K

Patent

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A61K 38/48 (2006.01)

Patent

CA 2580957

Methods for treating or preventing disease in biological conduits are provided herein. In certain embodiments, the methods relate to reducing or preventing vasospasm in blood vessel walls. In other embodiments, the methods described herein relate to reducing the accumulation of intimal hyperplasia in blood vessel walls after vascular procedures, including surgery. The methods encompass the use of agents that are useful for dilating biological conduits, but in dosages lower than are effective to achieve dilation of biological conduits.

La présente invention concerne des techniques de traitement et de prévention de maladies de conduits biologiques. Dans certains modes de réalisation de l'invention, ces techniques concernent la réduction ou la prévention de vasospasme dans des parois de vaisseaux sanguins. Dans d'autres modes de réalisation de l'invention, ces techniques concernent la réduction de l'accumulation d'hyperplasie intime dans des parois de vaisseaux sanguin après des opérations vasculaires, notamment chirurgicales. Ces techniques utilisent des agents qui conviennent pour dilater des conduits biologiques, mais dans des doses inférieures à la dose efficace entraînant une dilatation des conduits biologiques.

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