A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2614640
The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti- CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non- modified anti-CD3 antibodies.
L'invention concerne des méthodes de traitement, de prévention ou d'amélioration des symptômes de maladies immunologiques induites par les lymphocytes T, notamment des maladies auto-immunes, au moyen d'anticorps anti-CD3. Plus précisément, les méthodes selon l'invention consistent à administrer des anticorps se liant de manière spécifique à la sous-unité epsilon dans le complexe humain CD3. De tels anticorps modulent l'interaction récepteur/allo-antigène des lymphocytes T et, régulent, par conséquent, la cytotoxicité induite par les lymphocytes T associée à des troubles auto-immuns. De plus, l'invention concerne la modification des anticorps anti-CD3 consistant à les modifier de manière qu'ils présentent une fonction de l'effecteur réduite ou pas de fonction et une activation des lymphocytes T comparativement à des anticorps anti-CD3 non modifiés.
Bonvini Ezio
Johnson Leslie S.
Koenig Scott
Wilder Ronald
Macrogenics Inc.
Osler Hoskin & Harcourt Llp
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